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This is one of the most important chemical processes which enable our bodies to fully utilize THC and its benefits. decarboxylation smoking baking Cannabis plant doesn’t make Δ9-tetrahydrocannabinol, or THC. It actually makes Δ9-tetrahydrocannabinolic acid (THCA), which has not been proved to induce the psychoactive effects, such as feeling “high”. THCA is converted to THC by a process called decarboxylation, in which THCA is chemically changed and has a by-product of carbon dioxide gas (see Figure 1).1 This is accomplished when the THCA is heated, either when being smoked/vaped or during extraction into edible ingredients, for example by heating oil with cannabis while making brownies. Figure 1: The transformation of THCA molecule into THC + CO2. thc decarboxylation References:
  1. Veress, T.; Szanto, J. I.; Leisztner, L. (1990). Determination of cannabinoid acids by high-performance liquid chromatography of their neutral derivatives formed by thermal decarboxylation: I. Study of the decarboxylation process in open reactors. Journal of Chromatography A, 520(Supplement C), 339--347.