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Distribution

After absorption, the blood circulation transports compounds, such as THC, to the body’s organs. This phase in pharmacokinetics is called distribution. Since THC is very lipophilic, i.e. fat-loving in nature, THC and its metabolites rapidly distribute to fatty tissues, such as the brain.1, 2 Due to this lipophilicity, THC is accumulated and stored in the body fat where it is slowly released back into the blood.3 Watch a brief summary video on cannabis inhalation vs. cannabis ingestion made in collaboration with Enlighten on YouTube or on the screens page. References:
  1. Peat, Michael A. (1989). Distribution of delta-9-tetrahydrocannabinol and its metabolites. Advances in analytical toxicology, 2, 186--217.
  2. Wall, M. E.; Sadler, B. M.; Brine, D.; Taylor, H.; Perez-Reyes, M. (1983). Metabolism, disposition, and kinetics of delta-9-tetrahydrocannabinol in men and women. Clinical pharmacology and therapeutics, 34(3), 352--63.
  3. Grotenhermen, Franjo (2003). Clinical Pharmacokinetics of Cannabinoids. Journal of Cannabis Therapeutics, 3(1), 3--51.